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Products & Applications PREBIO¹

Prebiotics are non-digestible substances that can beneficially affect the host by selectively stimulating the growth of bacterial species already in the colon.¹ PREBIO¹™ is a unique prebiotic blend of the soluble fibers FOS and inulin, designed to support complete colonic health.

PREBIO¹ is designed to support proximal and distal colon health, help maintain colonic integrity and promote healthy gut flora.

Formulas containing PREBIO¹ provide nutrition support for patients with GI compromise. These formulas may be used for:

  • Chronic diarrhea/Malnutrition
  • Early enteral feeding
  • Transition from TPN
  • Short-bowel syndrome
  • Chronic pancreatitis
  • Malabsorption related to cancer treatment
  • HIV/AIDS
  • Delayed gastric emptying
  • Cystic fibrosis

PREBIO¹ is available only in Nestlé products.

Gut Integrity and Barrier Function

Prebiotics may help to support the critical gut mucosal barrier:

  • The prebiotics fructooligosaccharides (FOS) and inulin provide substrate for proximal and distal fermentation by the intestinal microbiota
  • Fermentation of FOS and inulin in the colon results in the production of short-chain fatty acids (SCFA)¹
  • SCFAs provide fuel for ileal and colonic epithelial cells, which may help maintain the integrity of the colon wall²

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Healthy Gut Microbiota

Prebiotics help support the growth of potentially beneficial bacteria:

  • The fermentation of FOS and inulin produces lactic acid4
  • Lactic acid helps to decrease colonic pH, making the colonic environment less favorable for potentially pathogenic bacteria2,4
  • FOS and inulin selectively promote the growth of beneficial bacteria with intake as low as four to eight grams per day2-4,5
  • Lactate helps decrease colonic pH to control pathogenic bacteria growth

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Absorption and Bowel Management

Prebiotics help improve water and electrolyte absorption:

  • Fermentation of FOS and inulin produces SCFA
  • SCFA facilitate the absorption of water and electrolytes
  • Absorption of water and electrolytes may help minimize risk of diarrhea6
  • Colonic absorption of water may help reduce diarrhea volume

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Mechanisms of Prebiotic Action


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  1. Gibson GR, et al. Gastroenterology 1995;108(4):975-82.
  2. Roberfroid MB. Crit Rev Food Sci Nutr 1993;33:103-48.
  3. Sakata T. Br Journal Nutr 1987;58:95-103.
  4. Roberfroid MB, Delzeene NM. Annu Rev Nutr 1998;18:117-43.
  5. Kleessen B, et al. RepAm J Clin Nutr 1997;65:1397-1402.
  6. Bowling T, et al. The Lancet 1993;242:1266-68.